In early 2015 a group of viral hepatitis experts within the HIV Europe Initiative formed a working group to develop a consensus definition for viral hepatitis. After discussions, meetings and several reviews the final two agreed upon definitions were approved by the EASL GB in early October 2015 and on Thursday 22 October EASL and HIV in Europe announced a consensus definition of late presentation for viral hepatitis. The announcement coincided with the European AIDS Conference in Barcelona and aims to encourage policy makers, health professionals, public health institutions and civil society organisations to implement this definition to improve the European surveillance of and response to the viral hepatitis epidemic.
Advanced HBV, HCV or HDV associated liver disease is clinically defined by presence of hepatocellular carcinoma or decompensated cirrhosis (jaundice, hepatic encephalopathy, clinically detectable ascites, variceal bleeding).
Late presentation of HBV or HCV associated liver disease is defined as a patient with chronic hepatitis B or C and significant fibrosis (≥F3 assessed by APRI score >1.5, FIB-4 >3.25, Fibrotest > 0.59 or alternatively a FibroScan >9.5 kPa) with no previous antiviral treatment.
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